Improved Bevirimat resistance prediction by combination of structural and sequence-based classifiers
Abstract Background Maturation inhibitors such as Bevirimat are a new class of antiretroviral drugs that hamper the cleavage of HIV-1 proteins into their functional active forms.They bind to these preproteins and inhibit their cleavage by the HIV-1 protease, resulting in non-functional virus particles.Nevertheless, there exist mutations in this reg